1255207-84-1

Basic information

• Product Name: (2Z)-2-(2-chlorobenzylidene)-5,6-dihydroimidazo[2,1-b]thiazol-3(2H)-one
• CAS NO: 1255207-84-1
• Molecular Weight: 264.735
• Mol File: 1255207-84-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2Z)-2-(2-chlorobenzylidene)-5,6-dihydroimidazo[2,1-b]thiazol-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2Z)-2-(2-chlorobenzylidene)-5,6-dihydroimidazo[2,1-b]thiazol-3(2H)-one(1255207-84-1)
• EPA Substance Registry System: (2Z)-2-(2-chlorobenzylidene)-5,6-dihydroimidazo[2,1-b]thiazol-3(2H)-one(1255207-84-1)

Safety Data

• Hazardous Substances Data: 1255207-84-1(Hazardous Substances Data)

Upstream product

• 6703-51-1 5,6-dihydro-imidazo[2,1-b]thiazol-3-one 
• 89-98-5 2-chloro-benzaldehyde 
• 19951-23-6 2-((4,5-dihydro-1H-imidazol-2-yl)thio)acetic acid 

Relevant articles and documents

Synthesis and biological evaluation of novel thiazolidinone derivatives as potential anti-inflammatory agents

The modulation of pro-inflammatory cytokines provides a target for controlling inflammatory diseases and attracts much attention in current anti-inflammatory drug development. Here, four series of thiazolidinone derivatives were synthesized and screened for anti-inflammatory activities. A majority of these compounds showed excellent inhibition on the expression of TNF-α and IL-6 in LPS-stimulated macrophages. Discussions are given regarding the structure-activity relationships. Compounds 12d and 12h inhibited LPS-induced TNF-α and IL-6 release in a dose-dependent manner. Furthermore, 12d exhibited a significant protection against LPS-induced septic death in mouse model. Together, these data present a series of new thiazolidinones with potential therapeutic effects in acute inflammatory diseases and they could be important leads in the continuing anti-inflammatory drug research.