1255237-04-7Relevant academic research and scientific papers
Total synthesis of syringolin A
Dai, Chunhui,Stephenson, Corey R. J.
body text, p. 3453 - 3455 (2010/10/02)
(Equation Presented). A convergent, efficient synthesis of syringolin A has been accomplished in 13 steps from commercially available materials, Garners aldehyde and l-valine. The unnatural 3,4-dehydrolysine fragment was prepared using successive Johnson-Claisen/Curtius rearrangement reactions. The macrolactamization and late-stage introduction of the side chain will provide convenient access to analogues of this promising proteasome inhibitor.
