1255239-79-2

Upstream product

• 142775-59-5 ethyl (3S)-3-O-tert-butyldimethylsilyl-3,4-dihydroxybutanate 
• 1431382-21-6 ethyl (2R,3S)-2-benzyl-4-(tert-butyldimethylsilyloxy)-3-hydroxybutanoate 
• 1431382-26-1 ethyl (2R,3S)-2-benzyl-4-(tert-butyldimethylsilyloxy)-3-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyloxy)butanoate 

Downstream Products

• 1255239-78-1 (2R,3S)-2-benzyl-3-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyloxy)butanolide 

Relevant academic research and scientific papers

Design, synthesis and hepatoprotective activity of analogs of the natural product goodyeroside A

Goodyeroside A, a natural product isolated from the Goodyera species, possesses significant hepatoprotective activity and has a novel skeleton not previously observed in other synthetic drugs used for the treatment of hepatitis. Herein, we report a highly stereoselective synthesis of goodyeroside A and related analogs with varying substituents at the α position of the carbonyl group to explore the structure-activity relationships of goodyeroside A. The absolute configuration of analog 5d was confirmed by single crystal X-ray analysis. The results from in vitro and in vivo studies indicate that 5a, the fully acetylated compound of goodyeroside A, is worthy of further investigation as a lead to identify novel hepatoprotective agents.