125532-24-3Relevant academic research and scientific papers
Novel Thiazolidine-2,4-diones as Potent Euglycemic Agents
Hulin, Bernard,Clark, David A.,Goldstein, Steven W.,McDermott, Ruth E.,Dambek, Paul J.,et al.
, p. 1853 - 1864 (2007/10/02)
A new series of thiazolidine-2,4-diones was obtained by replacing the ether function of englitazone with various functional groups, i.e., a ketone, alcohol, or olefin moiety.These compounds lower blood glucose levels in the genetically obese and insulin-r
Hypoglycemic thiazolidinedione derivatives
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, (2008/06/13)
Hypoglycemic thiazolidine-2,4-derivatives STR1 wherein the dotted line represents a bond or no bond; V is --CH=CH--, --N=CH--, --CH=N-- or S; W is CH2, CHOH, CO, C=NOR or --CH=CH--; X is S, O, NR1, --CH=N-- or --N=CH--; Y is CH or N; Z is hydrogen, (C1 -C7)alkyl, (C3 -C7)cycloalkyl, phenyl, naphtyl, pyridyl, furyl, thienyl or phenyl mono- or disubstituted with the same or different groups which are (C1 -C3)alkyl, trifluoromethyl, (C1 -C3)alkoxy, fluoro, chloro or bromo; Z1 is hydrogen or (C1 -C3)alkyl; R is hydrogen or methyl; and n is 1, 2 or 3; a pharamceutically acceptable cationic salt thereof; or a pharmaceutically acceptable acid addition salt thereof when the compound contains basic nitrogen.
