1255381-99-7Relevant academic research and scientific papers
Novel Bis[N-alkyl-N-(2-diphenylphosphinylethyl)]diglycolamides: Synthesis and NMR Spectroscopy Studies
Bondarenko,Tcarkova,Belus’,Artyushin,Peregudov
, p. 181 - 189 (2021/03/20)
Abstract: Pentadentate bis[N-alkyl-N-(2-diphenylphosphinylethyl)]diglycolamides [Ph2P(O)CH2CH2N(R)· C(O)CH2]2O, where R Me, Bu, Oct, were synthesized by reaction of diglycolyl chloride with N-alkyl-N-(2-diphenylphosphinylethyl)amines Ph2P(O)CH2CH2NHR obtained by reacting diphenyl(2-phenoxyethyl)phosphine oxide with primary alkylamines in DMSO in the presence of an aqueous alkali. Structure of the prepared compounds was studied by 1H, 13C, and 31P NMR spectroscopy.
2-Phenoxyethyldiphenylphosphine oxide as an equivalent of diphenylvinylphosphine oxide in nucleophilic additions
Bondarenko, Natalia A.,Tcarkova, Kseniia V.,Belus', Svetlana K.,Artyushin, Oleg I.
, p. 902 - 910 (2021/06/25)
A facile method for the synthesis of β-functionalized ethyldiphenylphosphine oxides is developed based on readily available 2-phenoxyethyldiphenylphosphine oxide used as an equivalent of diphenylvinylphosphine oxide in the reactions of addition of different PH- and NH-nucleophiles in DMSO in the presence of KOH. The transformations of labile phosphine oxides of a general formula Ph2P(O)CH2CH2OR, where R = Ph, H, or Ph2P(O)CH = CH2, in aq.KOH/DMSO and solid KOH/DMSO systems are explored in the absence of nucleophilic reagents.
New method for the syntheses of 2-aminoethyldiphenylphosphine oxides under the phase transfer conditions using cesium carbonate
Artyushin, Oleg I.,Belus', Svetlana K.,Bondarenko, Natalia A.,Tcarkova, Kseniia V.
, (2021/12/02)
A simple one-pot method for the synthesis of 2-aminoethyldiphenylphosphine oxides is developed based on readily available diphenyl(2-phenoxyethyl)phosphine oxide and amines of different types under phase transfer catalysis conditions using anhydrous cesium carbonate as a base in acetonitrile or DMSO.
A practical and efficient green synthesis of β-aminophosphoryl compounds via the aza-Michael reaction in water
Matveeva, Ekaterina V.,Petrovskii, Pavel V.,Klemenkova, Zinaida S.,Bondarenko, Natalya A.,Odinets, Irina L.
experimental part, p. 964 - 970 (2011/11/05)
Biphasic systems room temperature imidazolium ionic liquid (RTIL)/water or water as a solvent significantly accelerate the addition of amines to vinylphosphoryl compounds hence opening green and effective synthesis of β-aminophosphoryl compounds in excellent yields over short reaction times. The application of water, being the cheapest and most non-toxic solvent, without any catalyst or co-solvent, is more advantageous as it provides a simple isolation procedure for products having high purity (> 95% according to the NMR data) via simple freeze-drying and does not require extraction with organic solvents. The solubility of the starting phosphorus substrate in water does not play crucial role in the reaction as it was demonstrated using water insoluble diphenylvinylphosphine oxide. In contrast to typical procedures, using a reactant ratio (vinylphosphoryl compound: amine) of 2:1 readily resulted in double phosphorylation of primary amines, including polyamines, in water.
