1255530-21-2

Basic information

• Product Name: C₂₁H₂₅NO₂
• Synonyms: C₂₁H₂₅NO₂
• CAS NO: 1255530-21-2
• Molecular Weight: 323.435
• Mol File: 1255530-21-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₅NO₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₅NO₂(1255530-21-2)
• EPA Substance Registry System: C₂₁H₂₅NO₂(1255530-21-2)

Safety Data

• Hazardous Substances Data: 1255530-21-2(Hazardous Substances Data)

Upstream product

• 760-93-0 methacryloyl anhydride 
• 90-85-7 (1R,2S)-1-phenyl-2-(N-methyl-N-benzylamino)propan-1-ol 

Downstream Products

• 1064016-68-7 (2S,4R)-2,4-dimethyl-4-hydroxy-16-phenylhexadecanoic acid 1,4-lactone 

Relevant articles and documents

A stereo-controlled synthesis of 2,4-dimethyl-4-hydroxy-16- phenylhexadecanoic acid 1,4-lactone and its PPAR activities

A novel class of natural PPAR agonists, 2,4-dimethyl-4-hydroxy-16- phenylhexadecanoic acid 1,4-lactone (1), were discovered in marine natural product libraries. The synthesis of 1 was accomplished starting from vinylmethyl ketone. Ring formation of the α,γ dialkyl γ-lactone was achieved via the stereo-controlled reaction of a ketyl radical anion with a chiral methacrylate. In the PPAR agonistic assay, the most potent of the four stereoisomers had EC50 values of 12 μM for mPPARα, 9 μM for mPPARδ and >100 μM for mPPARγ.