1255695-22-7

Basic information

• Product Name: N-methyl-N-(4-(trifluoromethyl)benzyl)benzenamine
• Synonyms: N-methyl-N-(4-(trifluoromethyl)benzyl)benzenamine
• CAS NO: 1255695-22-7
• Molecular Weight: 265.278
• Mol File: 1255695-22-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: N-methyl-N-(4-(trifluoromethyl)benzyl)benzenamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-N-(4-(trifluoromethyl)benzyl)benzenamine(1255695-22-7)
• EPA Substance Registry System: N-methyl-N-(4-(trifluoromethyl)benzyl)benzenamine(1255695-22-7)

Safety Data

• Hazardous Substances Data: 1255695-22-7(Hazardous Substances Data)

Upstream product

• 454-92-2 3-(trifluoromethyl)benzoic acid 
• 100-61-8 N-methylaniline 
• 402-49-3 4-bromomethyltrifluoromethylbenzene 
• 455-24-3 4-trifluoromethylbenzoic acid 
• 345958-72-7 4-(trifluoromethyl)phenyl 4-methylbenzenesulfonate 
• 402-45-9 4-hydroxybenzotrifluoride 

Relevant articles and documents

Direct N-Alkylation/Fluoroalkylation of Amines Using Carboxylic Acids via Transition-Metal-Free Catalysis

A scalable protocol of direct N-mono/di-alkyl/fluoroalkylation of primary/secondary amines has been constructed with various carboxylic acids as coupling agents under the catalysis of a simple air-tolerant inorganic salt, K3PO4. Advantageous features include 100 examples, 10 drugs and drug-like amines, fluorinated complex tertiary amines, gram-scale synthesis and isotope-labelling amine, thus demonstrating the potential applicability in industry of this methodology. The involvement of relatively less reactive silicon-hydride compared with the traditional reactive metal-hydride or boron-hydride species required to reduce the amide intermediates presumably contributes to the remarkable functional group compatibility. (Figure presented.).

Nickel-Catalyzed Decarboxylation of Aryl Carbamates for Converting Phenols into Aromatic Amines

Herein, we describe a new catalytic approach to accessing aromatic amines from an abundant feedstock, namely phenols. The most reliable catalytic method for converting phenols to aromatic amines uses an activating group, such as a trifluoromethane sulfonyl group. However, this activating group is eliminated as a leaving group during the amination process, resulting in significant waste. Our nickel-catalyzed decarboxylation reaction of aryl carbamates forms aromatic amines with carbon dioxide as the only byproduct. As this amination proceeds in the absence of free amines, a range of functionalities, including a formyl group, are compatible. A bisphosphine ligand immobilized on a polystyrene support (PS-DPPBz) is key to the success of this reaction, generating a catalytic species that is significantly more active than simple nonsupported variants.

Coupling of C(sp3)-H bonds with C(sp2)-O electrophiles: mild, general and selective

Herein is reported the mild and general coupling of amine/ether C(sp3)-H bonds with various kinds of C(sp2)-O electrophiles with high selectivity and efficiency. Valuable allylic/benzylic amines are generated in moderate to excellent yields. The utility of this transformation is demonstrated by a broad substrate scope (>50 examples), good functional group tolerance and facile product modification.