1255704-63-2Relevant academic research and scientific papers
An improved diastereoselective synthesis of spiroazoles using multicomponent domino transformations
Altieri, Elisa,Cordaro, Massimiliano,Grassi, Giovanni,Risitano, Francesco,Scala, Angela
, p. 2106 - 2108 (2010)
Spiroisoxazole and spiropyrazole derivatives were obtained in a four-component reaction of active isoxazol- or pyrazol-5-ones with aromatic aldehydes, phenacyl chloride and AcOH-AcONH4 mixture. The reaction sequence is highly chemo- and diastereoselective affording good yields of spiroisoxazoles in refluxing ethanol, while efficient formation of spiropyrazoles is closely related to the use of a microwave-assisted protocol.
