1255709-49-9Relevant academic research and scientific papers
Insight into the SEA amide thioester equilibrium. Application to the synthesis of thioesters at neutral pH
Pira,El Mahdi,Raibaut,Drobecq,Dheur,Boll,Melnyk
, p. 7211 - 7216 (2016)
The bis(2-sulfanylethyl)amide (SEA) N,S-acyl shift thioester surrogate has found a variety of useful applications in the field of protein total synthesis. Here we present novel insights into the SEA amide/thioester equilibrium in water which is an essenti
Synthesis of peptide alkylthioesters using the intramolecular N, S-acyl shift properties of bis(2-sulfanylethyl)amido peptides
Dheur, Julien,Ollivier, Nathalie,Vallin, Aurelie,Melnyk, Oleg
scheme or table, p. 3194 - 3202 (2011/06/21)
The design of novel methods giving access to peptide alkylthioesters, the key building blocks for protein synthesis using Native Chemical Ligation, is an important area of research. Bis(2-sulfanylethyl)amido peptides (SEA peptides) 1 equilibrate in aqueou
Synthesis of thiazolidine thioester peptides and acceleration of native chemical ligation
Dheur, Julien,Ollivier, Nathalie,Melnyk, Oleg
supporting information; experimental part, p. 1560 - 1563 (2011/05/02)
Thiazolidine thioester peptides were synthesized by reacting bis(2-sulfanylethyl)amido peptides with glyoxylic acid at pH 1. A significant increase in Native Chemical Ligation (NCL) rate was observed with thiazolidine thioesters compared to 3-mercaptoprop
