1255790-45-4

Basic information

• Product Name: C₄₃H₄₉NO₈
• Synonyms: C₄₃H₄₉NO₈
• CAS NO: 1255790-45-4
• Molecular Weight: 707.864
• Mol File: 1255790-45-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₄₃H₄₉NO₈(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₃H₄₉NO₈(1255790-45-4)
• EPA Substance Registry System: C₄₃H₄₉NO₈(1255790-45-4)

Safety Data

• Hazardous Substances Data: 1255790-45-4(Hazardous Substances Data)

Upstream product

• 1255790-44-3 C₄₆H₅₅NO₈Si 
• 74-88-4 methyl iodide 
• 1330578-73-8 (2R,4R,5S,6R)-4-azido-5-benzyloxy-2-(furan-2-yl)-6-methyltetrahydro-2H-pyran 
• 1330578-74-9 tert-butyl (2R,4R,5S,6R)-5-benzyloxy-2-(furan-2-yl)-6-methyltetrahydro-2H-pyran-4-ylcarbamate 
• 1255790-40-9 tert-butyl (2R,4R,5S,6R)-5-benzyloxy-2-(furan-2-yl)-6-methyltetrahydro-2H-pyran-4-yl(methyl)carbamate 
• 1330578-79-4 8-benzyloxy-2,3-dibromo-4,4-dimethoxy-6-methylnaphthalene 
• 1255790-37-4 (1R,3R,4S,5R)-3-azido-1-(furan-1'-yl)-tetrahydro-5-methyl-2H-pyran-4-ol 
• 1255790-58-9 5-benzyloxy-2-bromo-7-methylnaphthalene-1,4-dione 
• 1255790-59-0 5-benzyloxy-2,3-dibromo-7-methylnaphthalene-1,4-dione 
• 1255790-43-2 8-benzyloxy-2,3-dibromo-4-methoxy-6-methylnaphthalen-1-ol 
• 1255790-39-6 tert-butyl ((2R,4R,5S,6R)-5-(benzyloxy)-6-methyl-2-(5-(dimethyl(vinyl)silyl)furan-2-yl)tetrahydro-2H-pyran-4-yl)(methyl)carbamate 
• 1255790-41-0 tert-butyl (1R,3R,4S,5R)-4-benzyloxytetrahydro-1-(4'-((8'-hydroxyethyl)dimethylsilyl)-furan-1'-yl)-5-methyl-2H-pyran-3-ylmethylcarbamate 
• 1255790-42-1 tert-butyl (1R,3R,4S,5R)-1-(4'-(8'-(5''-benzyloxy-2'',3''-dibromo-1''-methoxy-7''-methylnaphthalen-4''-yloxy)ethyldimethylsilyl)furan-1'-yl)-4-benzyloxy-tetrahydro-5-methyl-2H-pyran-3-ylmethylcarbamate 
• 1330579-15-1 C₁₂H₁₅N₃O₄ 

Downstream Products

• 1255790-46-5 8-benzyloxy-4-((1'R, 3'R, 4'S, 5'R)-4'-benzyloxy-tetrahydro-5'-methyl-3'-methylamino-2H-pyran-1'-yl)-9,10-dimethoxy-6-methylanthracen-1-ol 

Relevant articles and documents

Studies toward the syntheses of pluramycin natural products. the first total synthesis of isokidamycin

We report the first total synthesis of the complex C-aryl glycoside isokidamycin, the epimer of the naturally-occurring pluramycin antibiotic kidamycin. The synthesis features a highly efficient Diels-Alder reaction between a substituted naphthyne and a glycosylated furan to form the anthracene core bearing a pendent angolosamine C-glycoside. The regiochemical outcome of the Diels-Alder reaction was controlled by employing a disposable silicon tether to link the reactive naphthyne and the glycosyl furan, rendering the cycloaddition intramolecular. The benzopyranone moiety of the aromatic nucleus was appended by cyclization of a functionalized vinylogous amide onto an advanced anthrol intermediate. The vancosamine amino glycoside was introduced by an O→C-glycoside rearrangement that produced the β-anomer. Subsequent refunctionalizations then led to isokidamycin.