1255792-06-3Relevant academic research and scientific papers
Photosensitive polyethylene glycol-based antibacterial hydrogel dressing and preparation method thereof
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Paragraph 0018; 0023-0027, (2020/09/12)
The invention relates to photo-sensitive polyethylene glycol antibacterial hydrogel dressing and a preparation method thereof. The photo-sensitive polyethylene glycol antibacterial hydrogel dressing is prepared by covalently grafting antibiotics to a polyethylene glycol hydrogen matrix. The preparation method of the photo-sensitive polyethylene glycol antibacterial hydrogel dressing comprises thefollowing steps: modifying micromolecular antibiotics to a polyethylene glycol macromolecular chain with terminal double bonds through ultraviolet breakable molecules, thus obtaining ultraviolet breakable polyethylene glycol-based macromolecules; blending the ultraviolet breakable polyethylene glycol-based macromolecules with unmodified polyethylene glycol molecules containing terminal double bonds as a monomer, and preparing and obtaining the hydrogel dressing with photo-sensitivity and antibacterial performance through thermal induced double-bond cross-linking under the action of a cross-linking agent and an initiator. According to the photo-sensitive polyethylene glycol antibacterial hydrogel dressing disclosed by the invention, the raw materials have good biocompatibility, the obtainedhydrogel dressing has certain mechanical performance and water-absorbing swelling performance, effective control and release can be realized under the irradiation of ultraviolet light with the wavelength of 365 nm, and the hydrogel dressing has good ultraviolet photoresponse performance and good antibacterial performance, and is suitable for protecting a wound and treating infection.
