125582-99-2Relevant academic research and scientific papers
Highly enantioselective hydrogenation of 2-oxo-4-arybutanoic acids to 2-hydroxy-4-arylbutanoic acids
Zhu, Lufeng,Chen, Houhe,Meng, Qinghua,Fan, Weizheng,Xie, Xiaomin,Zhang, Zhaoguo
supporting information; experimental part, p. 6186 - 6190 (2011/09/19)
The Ru-catalyzed asymmetric hydrogenation of 2-oxo-4-arybutanoic acids to afford 2-hydroxy-4-arybutanoic acids was accomplished by employing SunPhos as chiral ligand and 1 M aq HBr as additive. The high enantioselectivities (88.4%-92.6% ee) and efficiency (TON=10,000, TOF=300 h-1) make this method efficient for the synthesis of an important intermediate, (R)-2-hydroxy-4-phenylbutanoic acid, for ACE inhibitors.
Facile Synthesis of α-Keto Acids and Esters by Palladium-Catalyzed Decarboxylation Reactions of Diallyl α-Oxalcarboxylates
Shimizu, Isao,Makuta, Toshiyuki,Oshima, Masato
, p. 1457 - 1460 (2007/10/02)
Reaction of diallyl α-oxalcarboxylates with formic acid in the presence of palladium catalyst gave α-keto acid in good yields.When the reaction was carried out without formic acid, decarboxylation-allylation took place to give allyl β-allyl-α-keto carboxylates.
