1255909-97-7Relevant academic research and scientific papers
Two-step hantzsch based macrocyclization approach for the synthesis of thiazole-containing cyclopeptides
Nefzi, Adel,Arutyunyan, Sergey,Fenwick, Jason E.
, p. 7939 - 7941 (2010)
Macrocyclization via an efficient high-yielding solid-phase intramolecular thioalkylation reaction is described. The reaction of S-nucleophiles with newly generated N-terminal 4-chloromethyl thiazoles led to the desired macrocyclization products 5 in high
