125593-47-7Relevant academic research and scientific papers
Efficient access to bicyclo[4.3.0]nonanes: Copper-catalyzed asymmetric silylative cyclization of cyclohexadienone-tethered allenes
He, Zhi-Tao,Tang, Xiao-Qi,Xie, Li-Bo,Cheng, Mian,Tian, Ping,Lin, Guo-Qiang
supporting information, p. 14815 - 14818 (2016/02/05)
The creation of three consecutive chiral carbon centers in one step is achieved using Cu-catalyzed asymmetric silylative cyclization of cyclohexadienone-tethered allenes. Through regioselective β-silylation of the allene and subsequent enantioselective 1,4-addition to cyclohexadienone, this tandem reaction could afford cis-hydrobenzofuran, cis-hydroindole, and cis-hydroindene frameworks with excellent yields (80-98 %) and enantioselectivities (94-98 % ee) bearing vinylsilane and enone substructures. Meanwhile, this mild transformation is generally compatible with a wide range of functional groups, which allows further conversion of the bicyclic products to bridged and tricyclic ring structures. Three in one: Three consecutive chiral carbon centers are formed in one step by a copper-catalyzed asymmetric silylative cyclization of cyclohexadienone-tethered allenes. Thus cis-hydrobenzofuran, cis-hydroindole, and cis-hydroindene frameworks are prepared with exceptional yields (80-98 %) and enantioselectivities (94-98 % ee).
The Chemisty of Acylated Quinone Imine Ketals. Nucleophilic and Organolithium Addition Reactions
Swenton, John S.,Bonke, Brian R.,Clark, William M.,Chen, Chung-Pin,Martin, Kevin V.
, p. 2027 - 2034 (2007/10/02)
Acylated quinone imine ketals are readily available via anodic oxidation of p-methoxybenzanilides and p-methoxyacetanilides.These compounds react with a variety of nucleophiles to give the corresponding substituted 2- and/or 3-substituted-4-methoxyanilide
