125606-52-2Relevant academic research and scientific papers
Chemistry of O-silylated ketene acetals: A mild and convenient synthesis of β-lactam antibiotics
Kita,Shibata,Tamura,Miki
, p. 2225 - 2232 (2007/10/02)
β-Amido sulfoxides (1) reacted with O-silylated ketene acetal (16) in dry acetonitrile in the presence of a catalytic amount of zinc iodide to give the 4-phenylthioazetidin-2-ones (17). Oxidation of 17 with m-chloroperbenzoic acid gave the corresponding s
Possible biomimetic synthesis of β-lactams
Kaneko
, p. 5490 - 5492 (2007/10/02)
The first successful syntheses of β-lactams via a Pummerer rearrangement of the corresponding sulfoxides are described. Thus, variously substituted 3-(phenylsulfinyl)propionamides were converted to 4-(phenylthio)-2-azetidinones in 14-50% yields with trime
