1256137-66-2Relevant academic research and scientific papers
SAR156497, an exquisitely selective inhibitor of Aurora kinases
Carry, Jean-Christophe,Clerc, Fran?ois,Minoux, Hervé,Schio, Laurent,Mauger, Jacques,Nair, Anil,Parmantier, Eric,Le Moigne, Ronan,Delorme, Cécile,Nicolas, Jean-Paul,Krick, Alain,Abécassis, Pierre-Yves,Crocq-Stuerga, Véronique,Pouzieux, Stéphanie,Delarbre, Laure,Maignan, Sébastien,Bertrand, Thomas,Bjergarde, Kirsten,Ma, Nina,Lachaud, Sylvette,Guizani, Houlfa,Lebel, Rémi,Doerflinger, Gilles,Monget, Sylvie,Perron, Sébastien,Gasse, Francis,Angouillant-Boniface, Odile,Filoche-Rommé, Bruno,Murer, Michel,Gontier, Sylvie,Prévost, Céline,Monteiro, Marie-Line,Combeau, Cécile
, p. 362 - 375 (2015/03/04)
The Aurora family of serine/threonine kinases is essential for mitosis. Their crucial role in cell cycle regulation and aberrant expression in a broad range of malignancies have been demonstrated and have prompted intensive search for small molecule Auror
COMPOUND ETHYL 8-OXO-9-[3-(1H-BENZIMIDAZOL-2-YLOXY)PHENYL]-4,5,6,7,8,9-HEXAHYDRO-2H-PYRROLO[3,4-B]QUINOLINE-3-CARBOXYLATE, SALT, CRYSTALLINE FORM, COCRYSTAL, FORMULATION, PROCESSES FOR PREPARATION, APPLICATION AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS A
-
Page/Page column 12-13, (2012/06/01)
The invention relates more particularly to a new salt, cocrystal and formulations of ethyl 8-oxo-9-[3-(1H-benzimidazol-2-yloxy)phenyl]-4,5,6,7,8,9-hexahydro-2H- pyrrolo[3,4-b]quinoline-3-carboxylate of formula (F) to preparations thereof and to the use th
ANTI-CANCER COMPOUND AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
-
Page/Page column 9, (2012/09/10)
The invention relates to a compound of formula (I), more specifically in the levorotatory form (1a) thereof, in particular the form having a rotatory power [α]D=?38.6+0.7 at a concentration of 0.698 mg/ml in methanol. The compound may be in the form of a
