125617-34-7

Upstream product

• 125617-35-8 (E)-3-(3-Methoxyphenyl)-2-propen-1-ol 
• 15851-92-0 (E)-3-methoxycinnamoyl chloride 
• 6099-04-3 trans-3-methoxycinnamic acid 

Downstream Products

• 136179-18-5 3-(2-Methoxy-ethoxy)-3-(3-methoxy-phenyl)-propane-1,2-diol 
• 136179-16-3 3-methoxy-3-(3-methoxyphenyl)-1,2-propanediol 
• 136178-94-4 4-(α(2-methoxyethoxy)3-methoxybenzyl)-2,2-dimethyldioxolane 
• 136178-93-3 4-(α,3-dimethoxybenzyl)-2,2-dimethyldioxolane 
• 136179-17-4 4-(α-amino-3-methoxybenzyl)-2,2-dimethyldioxolane 

Relevant academic research and scientific papers

Phenylaminopropanol derivatives and methods of their use

The present invention is directed to phenylaminopropanol derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.

Alkanophenones useful for treating allergies

Substituted alkanophenones of general formula STR1 in which R1 is unsubstituted or fluorinated lower alkyl, R2 is hydrogen, or unsubstituted or fluorinated lower alkyl or lower alkenyl, X is lower alkylene, oxy, thio or a direct bond, alk is lower alkylene, n is 1 or 2, R3 is phenyl that is unsubstituted or is substituted by unsubstituted or fluorinated lower alkyl, by etherified or esterified hydroxy, by unsubstituted or lower alkylated amino and/or by free, esterified or amidated carboxy, or is lower alkyl that is unsubstituted, substituted by fluoro and chloro or substituted by free esterified or amidated carboxy, R4 is free, esterified or amidated carboxy or 5-tetrazolyl, and R5 is hydrogen or lower alkyl, have leucotriene-antagonistic properties and can be used as anti-allergic active ingredients in medicaments.

LITHIATION OF THE BENZENE RING IN THE PRESENCE OF ortho-ALKYL SUBSTITUENTS BEARING ONE OR TWO HETEROATOMS ON THE β-CARBON. A CONVENIENT SYNTHESIS OF MELLEIN AND KIGELIN

The title reaction can be successfully accomplished by proton-metal exchange with n-butyllithium, and the usually observed elimination to a styrene derivative suppressed, provided an appropriate combination of heteroatoms bound to the β-carbon of the alky