1256242-48-4Relevant articles and documents
Gem -Dibromomethylarenes as aldehyde surrogates in the pictet-spengler synthesis of tetrahydroisoquinolines and isoindoloisoquinolones
Chowdappa, Nagaraja,Sherigara, Bailur Sheena,Augustine, John Kallikat,Areppa, Kummara,Mandal, Ashis Baran
experimental part, p. 2949 - 2956 (2010/11/02)
A new variant of the Pictet-Spengler reaction has been developed using gem-dibromomethylarenes as aldehyde surrogates to afford a variety of tetrahydroisoquinoline and isoindoloisoquinolone ring systems in good yields. These systems comprise important motifs in naturally occurring bioactive substances.