1256245-71-2Relevant academic research and scientific papers
Light-activated regulation of cofilin dynamics using a photocaged hydrogen peroxide generator
Miller, Evan W.,Taulet, Nicolas,Onak, Carl S.,New, Elizabeth J.,Lanselle, Julie K.,Smelick, Gillian S.,Chang, Christopher J.
, p. 17071 - 17073 (2011/03/01)
Hydrogen peroxide (H2O2) can exert diverse signaling and stress responses within living systems depending on its spatial and temporal dynamics. Here we report a new small-molecule probe for producing H 2O2 on demand upon photoactivation and its application for optical regulation of cofilin-actin rod formation in living cells. This chemical method offers many potential opportunities for dissecting biological roles for H2O2 as well as remote control of cell behavior via H2O2-mediated pathways.
