1256260-75-9Relevant academic research and scientific papers
A general strategy for construction of a difluoromethyl compound library and its application in synthesis of pseudopeptides bearing a terminal difluoromethyl group
Wu, Jingjing,Cao, Song,Liu, Nianjin,Shen, Li,Yu, Jinlong,Zhang, Jian,Li, Hui,Qian, Xuhong
experimental part, p. 2386 - 2391 (2010/07/09)
We describe the development of a novel synthesis strategy that uses common reaction conditions to transform a collection of simple building blocks into complex molecules bearing a terminal difluoromethyl group. The core of this approach is the conscious design and synthesis of new difluorinated building blocks which contain inactive and reactive groups on each side of the CF 2 group. The strategy is illustrated by application to the synthesis of CF2H-bearing pseudopeptides via Ugi reaction.
