1256269-07-4Relevant academic research and scientific papers
Synthesis of ortho-functionalized 4-aminomethylpyridazines as substrate-like semicarbazide-sensitive amine oxidase inhibitors
Haider, Norbert,Hochholdinger, Iris,Matyus, Peter,Wobus, Andrea
, p. 964 - 970 (2010)
A series of 4-aminomethylpyridazines and -pyridazin-3(2H)-ones ( diaza-benzylamines ), bearing alkylamino side chains in ortho position relative to the CH2NH2 unit, was synthesized by catalytic hydrogenation of the corresponding nitriles in strongly acidic medium. N-Benzyl protecting groups either at the pyridazinone ring nitrogen or at an exocyclic nitrogen were selectively removed hydrogenolytically or by treatment with a Lewis acid. The new compounds were tested in vitro for semicarbazide-sensitive amine oxidase (SSAO) inhibitory activity and 4-(aminomethyl)-N,N-diethylpyridazine-3,5-diamine (22) was found to be the most active representative.
