125627-00-1Relevant academic research and scientific papers
Cholic Acid as an Architectural Component in Biomimetic/Molecular Recognition Chemistry; Synthesis of the First "Cholaphanes".
Bonar-Law, Richard P.,Davis, Anthony P.
, p. 9829 - 9844 (2007/10/02)
The readily available steroid cholic acid (1) has several advantages as a precursor for extended, preorganised molecular frameworks.In the present work, full details are given for the conversion of 1 into ''cholaphanes'' 2a,b, the first macrocyclic steroi
Synthesis of Steroidal Cyclodimers from Cholic Acid; a Molecular Framework with Potential for Recognition and Catalysis
Bonar-Law, Richard,Davis, Anthony P.
, p. 1050 - 1052 (2007/10/02)
Macrocycles (2a-f) were synthesized from cholic acid (1a) in up to 33 percent overall yield; the 'cholaphane' framework on which they are based has substantial potential variability and should prove useful in biomimetic chemistry.
