1256270-32-2Relevant academic research and scientific papers
InCl3/CyNH2 cocatalyzed carbocyclization reaction: An entry to α-disubstituted exo -methylene cyclopentanes
Montaignac, Benjamin,Vitale, Maxime R.,Ratovelomanana-Vidal, Virginie,Michelet, Veronique
supporting information; experimental part, p. 8322 - 8325 (2011/02/28)
An efficient and cheap synthetic approach to functionalized exo-methylene cyclopentanes has been developed from α-disubstituted formyl-alkynes by merging amine catalysis with the indium activation of alkynes. We uncovered the crucial role of the amine cocatalyst and the development of a new cooperative catalytic system allowed the cyclization of a broad range of substrates. A mechanistic study was realized in order to rationalize the determining influence of the amine cocatalyst.
