1256278-63-3

Upstream product

• 352-34-1 4-fluoro-1-iodobenzene 
• 1256278-61-1 2,2-difluoro-1-tributylstannylethenyl p-toluenesulfonate 
• 17556-41-1 2,2,2-trifluoro-1-(4-fluorophenyl)ethanol 
• 98-59-9 p-toluenesulfonyl chloride 
• 50562-20-4 Toluene-4-sulfonic acid 2,2,2-trifluoro-1-(4-fluoro-phenyl)-ethyl ester 
• 1765-93-1 4-fluoroboronic acid 

Relevant academic research and scientific papers

Cross-Electrophile Coupling between Aryl/Vinyl Triflates and Vinyl Tosylates for the Synthesis of gem-Difluoroalkenes via Ni/Pd Cooperative Catalysis

A dual nickel-/palladium-catalyzed direct gem-difluorovinylation of readily available aryl/vinyl triflates with substituted gem-difluorovinyl tosylates is presented. This protocol affords various diaryldifluoroalkene, arylalkyldifluoroalkene and 1,1-diflu

Catalytic AgF-Initiated Intramolecular 1,3-Sulfonyl Migration of gem-Difluorovinyl Sulfonates to α,α-Difluoro-β-ketosulfones

A 1,3-sulfonyl migration of difluorovinyl sulfonates initiated by a catalytic amount of silver fluoride is presented. α,α-Difluoro-β-ketosulfones were successfully prepared in excellent yields. This method features high chemoselectivity, good functional group tolerance, high atom economy, and mild, environmentally benign reaction conditions. Furthermore, mechanistic experiments indicate that this migration proceeds in an intermolecular pathway and the corresponding sulfinates are possible intermediates.

Consecutive cross-coupling reactions of 2,2-difluoro-1-iodoethenyl tosylate with boronic acids: Efficient synthesis of 1,1-diaryl-2,2-difluoroethenes

The cross-coupling reactions of 2,2-difluoro-1-iodoethenyl tosylate (2) with 2 equiv of boronic acids in the presence of catalytic amounts of Pd(OAc)2 and Na2CO3 afforded the mono-coupled products 3 and 5 in high yields. The use of 4 equiv of boronic acid

Efficient synthesis of 2,2-diaryl-1,1-difluoroethenes via consecutive cross-coupling reactions of 2,2-difluoro-1-tributylstannylethenyl p -toluenesulfonate

2,2-Difluoro-1-tributylstannylethenyl p-toluenesulfonate (2) was reacted with aryl iodides in the presence of 10 mol % of Pd(PPh3)4 and 10 mol % of CuI in DMF at 80 °C for 10-20 h to give the cross-coupled products 3 in 35-97% yields. Further coupling reaction of 3 with arylstannanes in the presence of 5 mol % of Pd(PPh3)4 and 3 equiv of LiBr in DMF at 100 °C for 2-24 h afforded the desired products 5 in 25-78% yields.