1256282-75-3Relevant academic research and scientific papers
Synthesis and biological evaluation of novel β-carbolines as potent cytotoxic and DNA intercalating agents
Chen, Zhiyong,Cao, Rihui,Shi, Buxi,Yi, Wei,Yu, Liang,Song, Huacan,Ren, Zhenhua
, p. 901 - 907 (2010)
A series of novel water-soluble β-carbolines bearing a flexible amino side chain was designed, synthesized and evaluated as potent cytotoxic and DNA intercatalating agents. The N9-arylated alkyl substituted β-carbolines represented the most interesting cytotoxic activities. The results suggested that (1) the N9-arylated alkyl substituents of β-carboline nucleus played a very important role in the modulation of the cytotoxic potencies; (2) the length of the alkylamino side chain significantly affected their cytotoxic potency, and N,N-dimethylaminopropylamino substituent were more favorable. In addition, these compounds were found to exhibit significant DNA intercalating potencies.
