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1256290-37-5

4-({[2-methyl-3-(trifluoromethyl)phenyl]methyl}amino)-2-(4-morpholinyl)-1,3-thiazole-5-carboxamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1256290-37-5 Structure

  • Basic information

    1. Product Name: 4-({[2-methyl-3-(trifluoromethyl)phenyl]methyl}amino)-2-(4-morpholinyl)-1,3-thiazole-5-carboxamide
    2. Synonyms: 4-({[2-methyl-3-(trifluoromethyl)phenyl]methyl}amino)-2-(4-morpholinyl)-1,3-thiazole-5-carboxamide
    3. CAS NO:1256290-37-5
    4. Molecular Formula:
    5. Molecular Weight: 400.425
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1256290-37-5.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-({[2-methyl-3-(trifluoromethyl)phenyl]methyl}amino)-2-(4-morpholinyl)-1,3-thiazole-5-carboxamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-({[2-methyl-3-(trifluoromethyl)phenyl]methyl}amino)-2-(4-morpholinyl)-1,3-thiazole-5-carboxamide(1256290-37-5)
    11. EPA Substance Registry System: 4-({[2-methyl-3-(trifluoromethyl)phenyl]methyl}amino)-2-(4-morpholinyl)-1,3-thiazole-5-carboxamide(1256290-37-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1256290-37-5(Hazardous Substances Data)

1256290-37-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1256290-37-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,6,2,9 and 0 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1256290-37:
(9*1)+(8*2)+(7*5)+(6*6)+(5*2)+(4*9)+(3*0)+(2*3)+(1*7)=155
155 % 10 = 5
So 1256290-37-5 is a valid CAS Registry Number.

1256290-37-5Relevant articles and documents

Rational design, synthesis, and SAR of a novel thiazolopyrimidinone series of selective PI3K-beta inhibitors

Lin, Hong,Schulz, Mark J.,Xie, Ren,Zeng, Jin,Luengo, Juan I.,Squire, Michael D.,Tedesco, Rosanna,Qu, Junya,Erhard, Karl,MacK, James F.,Raha, Kaushik,Plant, Ramona,Rominger, Cynthia M.,Ariazi, Jennifer L.,Sherk, Christian S.,Schaber, Michael D.,McSurdy-Freed, Jeanelle,Spengler, Michael D.,Davis, Charles B.,Hardwicke, Mary Ann,Rivero, Ralph A.

supporting information; experimental part, p. 524 - 529 (2012/10/23)

A novel thiazolopyrimidinone series of PI3K-beta selective inhibitors has been identified. This chemotype has provided an excellent tool compound, 18, that showed potent growth inhibition in the PTEN-deficient breast cancer cell line MDA-MB-468 under anchorage-independent conditions, and it also demonstrated pharmacodynamic effects and efficacy in a PTEN-deficient prostate cancer PC-3 xenograft mouse model.

THIAZOLOPYRIMIDINONE DERIVATIVES AS PI3 KINASE INHIBITORS

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Page/Page column 68, (2010/12/18)

This invention relates to the use of thiazolopyrimidinone derivatives for the modulation, notably the inhibition of the activity or function of the phosphoinositide 3' OH kinase family (hereinafter PI3 kinases), suitably, PI3Kα, PI3Kδ, PI3Kβ, and/or PI3Kγ

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