1256293-35-2Relevant academic research and scientific papers
Synthesis of a functionalized 7,6-bicyclic spiroimine ring fragment of the spirolides
Gueret, Stephanie M.,Furkert, Daniel P.,Brimble, Margaret A.
, p. 5226 - 5229 (2010)
The asymmetric synthesis of a functionalized 7,6-spiroimine related to the spirolides is described. Intermolecular Diels-Alder cycloaddition of a chiral trisubstituted dienophile and Danishefsky's diene enabled simultaneous installation of the C7 and C29 stereocenters. Further transformations and late-stage aza-Wittig cyclization afforded the spiroimine in good yield. During this study, an unprecedented 14-membered dialdimine was also obtained.
