1256358-20-9Relevant academic research and scientific papers
Thiophene-containing products of the Ugi reaction in an oxidation-triggered IMDA/aromatization cascade: A simple access to 3-oxoisoindolines
Krasavin, Mikhail,Parchinsky, Vadislav
, p. 5657 - 5661 (2010)
A novel approach to skeletally diverse 3-oxoisoindolines has been developed which includes preparation of Ugi adducts containing thiophene and fumaric acid residues. When treated with excess m-CPBA at room temperature, these precursors undergo a simple oxidative cycloaddition/aromatization transformation and the corresponding 3-oxoisoindoline products are isolated in fair chemical yield over two steps. The second step is thought to include S-oxidation/IMDA/S-oxidation/ SO2 extrusion/aromatization events.
