1256380-91-2Relevant academic research and scientific papers
Rh(III)-catalyzed oxidative coupling of N -aryl-2-aminopyridine with alkynes and alkenes
Chen, Jinlei,Song, Guoyong,Pan, Cheng-Ling,Li, Xingwei
, p. 5426 - 5429 (2010)
[RhCp*Cl2]2 (1-2 mol %) can catalyze the oxidative coupling of N-aryl-2-aminopyridines with alkynes and arylates to give N-(2-pyridyl)indoles and N-(2-pyridyl)quinolones, respectively, using Cu(OAc)2 as an oxidant. Coupling with styrenes gave mono- and/or disubstituted olefination products.
Synthesis of N-(2-pyridyl)indoles via Pd(II)-catalyzed oxidative coupling
Chen, Jinlei,Pang, Qingyu,Sun, Yanbo,Li, Xingwei
supporting information; experimental part, p. 3523 - 3526 (2011/06/24)
Readily available Pd(II) chloride catalysts can catalyze selective and efficient oxidative coupling between N-aryl-2-aminopyridines and internal alkynes to yield N-(2-pyridyl)indoles. This process involves the ortho C-H activation of N-aryl-2-aminopyridines, and CuCl2 was used as an oxidant. Compared to our previously reported Rh(III)-catalyzed synthesis of this class of product, this method is advantageous with a wider scope of alkynes and cost-effective Pd(II) catalysts. Molecular oxygen can be used as a terminal oxidant.
