1256479-12-5 Usage
General Description
Ethyl 2-(4-chloro-3-fluorophenyl)acetate is a chemical compound with the molecular formula C10H10ClF2O2. It is commonly used in the production of pharmaceuticals and agrochemicals. ethyl 2-(4-chloro-3-fluorophenyl)acetate is a derivative of acetic acid and contains a benzene ring with both a chlorine and a fluorine substituent. Ethyl 2-(4-chloro-3-fluorophenyl)acetate is known for its role as an intermediate in organic synthesis, and its unique structure makes it useful in the development of various chemical compounds for industrial and research applications. Its properties and structure make it a versatile and important chemical in the field of organic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 1256479-12-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,6,4,7 and 9 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1256479-12:
(9*1)+(8*2)+(7*5)+(6*6)+(5*4)+(4*7)+(3*9)+(2*1)+(1*2)=175
175 % 10 = 5
So 1256479-12-5 is a valid CAS Registry Number.
1256479-12-5Relevant articles and documents
2-(Halogenated Phenyl) acetamides and propanamides as potent TRPV1 antagonists
Ann, Jihyae,Bahrenberg, Gregor,Blumberg, Peter M.,Choi, Sun,Christoph, Thomas,Do, Nayeon,Frank-Foltyn, Robert,Ha, Heejin,Jeong, Jin Ju,Kang, Jin Mi,Kim, Changhoon,Kwon, Sun Ok,Lee, Jeewoo,Lee, Sunho,Lesch, Bernhard,Stockhausen, Hannelore,Vu, Thi Ngoc Lan,Yoon, Sanghee
, (2021/07/28)
A series consisting of 117 2-(halogenated phenyl) acetamide and propanamide analogs were investigated as TRPV1 antagonists. The structure–activity analysis targeting their three pharmacophoric regions indicated that halogenated phenyl A-region analogs exhibited a broad functional profile ranging from agonism to antagonism. Among the compounds, antagonists 28 and 92 exhibited potent antagonism toward capsaicin for hTRPV1 with Ki[CAP] = 2.6 and 6.9 nM, respectively. Further, antagonist 92 displayed promising analgesic activity in vivo in both phases of the formalin mouse pain model. A molecular modeling study of 92 indicated that the two fluoro groups in the A-region made hydrophobic interactions with the receptor.
