1256483-11-0

Basic information

• Product Name: 2-BroMo-6-fluoro-3-Methylphenylacetonitrile, 96%
• Synonyms: 2-BroMo-6-fluoro-3-Methylphenylacetonitrile, 96%
• CAS NO: 1256483-11-0
• Molecular Formula: C9H7BrFN
• Molecular Weight: 228.0609832
• Mol File: 1256483-11-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-BroMo-6-fluoro-3-Methylphenylacetonitrile, 96%(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BroMo-6-fluoro-3-Methylphenylacetonitrile, 96%(1256483-11-0)
• EPA Substance Registry System: 2-BroMo-6-fluoro-3-Methylphenylacetonitrile, 96%(1256483-11-0)

Safety Data

• Hazardous Substances Data: 1256483-11-0(Hazardous Substances Data)

Upstream product

• 154650-16-5 2-bromo-6-fluoro-3-methylbenzaldehyde 
• 773837-37-9 sodium cyanide 
• 1375069-06-9 (2-bromo-6-fluoro-3-methylphenyl)methanol 

Downstream Products

• 1380027-77-9 C₉H₁₁BrFN 
• 1404115-41-8 C₁₄H₁₉BrFNO₂ 
• 1404115-67-8 C₁₄H₁₆FN₃O 
• 1404115-08-7 C₂₃H₂₂F₄N₄O₃ 
• 1404115-09-8 C₂₂H₂₀F₄N₄O₃ 

Relevant articles and documents

Phenethyl nicotinamides, a novel class of NaV1.7 channel blockers: Structure and activity relationship

The NaV1.7 ion channel is an attractive target for development of potential analgesic drugs based on strong genetic links between mutations in the gene coding for the channel protein and inheritable pain conditions. The (S)-N-chroman-3-ylcarboxamide series, exemplified by 1, was used as a starting point for development of new channel blockers, resulting in the phenethyl nicotinamide series. The structure and activity relationship for this series was established and the metabolic issues of early analogues were addressed by appropriate substitutions. Compound 33 displayed acceptable overall in vitro properties and in vivo rat PK profile.