1256485-65-0

Upstream product

• 327-54-8 1,2,4,5-Tetrafluorobenzene 
• 1256485-63-8 (iPr₃P)₂Ni(η²-C₁₄H₁₀) 
• 1256485-83-2 [NiH(triisopropylphosphine)2(2,3,5,6-tetrafluorophenyl-d1)] 
• 1295-35-8 bis(1,5-cyclooctadiene)nickel ⁽⁰⁾ 
• 6476-36-4 tris(1-methylethyl)phosphine 
• 121497-50-5 1-deutero-2,3,5,6-tetrafluorobenzene 

Downstream Products

• 1256485-83-2 [NiH(triisopropylphosphine)2(2,3,5,6-tetrafluorophenyl-d1)] 
• 1256485-71-8 [Ni(triisopropylphosphine)2(η2-3-hexyne)] 
• 1256485-72-9 [Ni(triisopropylphosphine)2(C(Et)CHEt)(2,3,5,6-tetrafluorophenyl)] 

Relevant academic research and scientific papers

Mechanistic insight into carbon-fluorine cleavage with a (iPr3P)2Ni source: Characterization of (iPr3P)2NiC6F5 as a significant Ni(I) byproduct in the activation of C6F6

The reaction of (iPr3P)2Ni sources such as the anthracene adduct, (iPr3P)2Ni(η2-C14H10), with hexafluorobenzene provided the C-F activation product trans-(iPr3P)2NiF(C6F5) (2) and the unexpected Ni(I) complex (iPr3P)2Ni(C6F5) (3). The observation of 3 supports a radical pathway for C-F activation, despite the observation of the mononuclear adduct (iPr3P)2Ni(η2-C6F6) (4) commonly associated with concerted or phosphine-assisted oxidative addition. Carbon-fluorine activation reactionsof pentafluorobenzene and all the isomers of tetrafluorobenzene and trifluorobenzene with (iPr3P)2Ni(η2-C14H10) were also examined. These reacted with varying selectivity and yield. It was found that 1,2,3,4-tetrafluorobenzene reacted selectively at the 2-position to provide a fully characterized C-F activation product, whereas 1,2,4,5-tetrafluorobenzene underwent a hydrodefluorination reaction with none of the expected C-F activation product.

Carbon-hydrogen bond oxidative addition of partially fluorinated aromatics to a Ni(PiPr3)2 synthon: The influence of steric bulk on the thermodynamics and kinetics of C-H bond activation

The reaction of (PiPr3)2NiCl2 with the anthracene adduct (THF)3Mg(η2-C 14H10) in THF provides the anthracene adduct (P iPr3)2Ni(η