1256503-67-9Relevant academic research and scientific papers
Tetrazine-trans-cyclooctene ligation for the rapid construction of 18F labeled probes
Li, Zibo,Cai, Hancheng,Hassink, Matthew,Blackman, Melissa L.,Brown, Richard C. D.,Conti, Peter S.,Fox, Joseph M.
supporting information; experimental part, p. 8043 - 8045 (2011/01/03)
A radiolabeling method for bioconjugation based on the Diels-Alder reaction between 3,6-diaryl-s-tetrazines and an 18F-labeled trans-cyclooctene is described. The reaction proceeds with exceptionally fast rates, making it an effective conjugation method within seconds at low micromolar concentrations.
