125655-80-3

Upstream product

• 80955-62-0 3-oxo-2-[(p-tolyl)hydrazono]butyronitrile 
• 5110-96-3 3-Imino-2-(p-tolyl-hydrazono)-butyronitrile 
• 132815-80-6 1-chloro-1-(p-tolylhydrazone)propanone 
• 106-49-0 p-toluidine 
• 2028-84-4 p-methylbenzenediazonium chloride 

Downstream Products

• 125655-87-0 5-amino-2-methyl-7-(p-methoxyphenyl)-3-(p-tolylazo)pyrazolo<1,5-a>pyrimidine-6-carbonitrile 
• 125655-85-8 5-amino-2-methyl-7-phenyl-3-p-tolylazopyrazolo<1,5-a>pyrimidine-6-carbonitrile 
• 125655-82-5 5-amino-1-(2-cyanoethyl)-3-methyl-4-(p-tolylazo)pyrazole 
• 125655-98-3 ethyl 7-amino-2-methyl-3-(p-tolylazo)pyrazolo<5,1-c>-1,2,4-triazine-6-carboxylate 
• 125656-05-5 5-amino-3-methyl-1-(N-ethoxycarbonylthiocarbamoyl)-4-(p-tolylazo)pyrazole 
• 125656-03-3 5-amino-3-methyl-1-(N-benzoylthiocarbamoyl)-4-(p-tolylazo)pyrazole 
• 125656-00-0 7-amino-2-methyl-3-(p-tolylazo)pyrazolo<5,1-c>-1,2,4-triazine-6-carbonitrile 
• 1156538-56-5 2-methyl-3-(4-methylphenylazo)pyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione 
• 1403582-58-0 25,27-bis[(4-nitrobenzyloxy)-26,28-dihydroxy-5,17-bis[3'-methyl-4'-(4-methylphenylazo)-1'H-pyrazole-5'-ylazo]]calix[4]arene 

Relevant academic research and scientific papers

Synthesis of some new pyrazolo[5,1-c][1,2,4]triazine derivatives and computational study

In this study, the synthesis novel of seven new pyrazolo [5,1-c][1,2,4]triazin derivative disperse dyestuffs was reported. First, 2-arylhydrazone-3-ketiminobutyronitriles were synthesized and reacted with hydrazine hydrate to afford 5-amino-4-arylazo-3-me

The synthesis, characterization and investigation of absorption properties of disperse disazo dyes containing pyrazole and isoxazole

In this study, new heterocyclic disazo disperse dyes, substituted with methyl, nitro and chloro groups at their o-, m-, p- positions were synthesized (4a-4j). These newly synthesized ten disazo disperse dyes were characterized by elemental analysis and spectral techniques. Spectroscopic data for novel synthesized dyes, dissolved in six solvents, were procured. The influences of six different acidic and alkaline solutions were also reported. In addition, the absorption capability of these ten-novel heterocyclic disazo disperse dyes at their o-, m- and p- positions were explored in detail.

Anticancer, antimicrobial, and DNA protection analysis of novel 2,4-dihydroxyquinoline dyes

A new series of 2,4-dihydroxyquinoline derived disazo dyes has been synthesized by the reaction of 5-amino-4-phenylazo-3-methyl-1H-pyrazole derivatives with 2,4-dihydroxyquinoline. The structures of the obtained dyes were identified by various spectrophotometric methods such as FT-IR, 1H-NMR, and elemental analysis. The synthesized compounds were also examined for different biological activities, including DNA protection, antimicrobial, and anticancer activities. Compound 3b was found most effective on Gram-positive bacteria. A DNA protection assay was applied to all compounds, and it was found that compounds 3h and 3j had a high capacity for binding to DNA. Besides, compounds 3h and 3j showed cytotoxicity against HeLa and PC3 cancer cell lines. These compounds could potentially be used as drugs or drug additives based on their effects on bacterial and cancer cell lines.

New coumarin-based disperse disazo dyes: Synthesis, spectroscopic properties and theoretical calculations

5-Amino-4-arylazo-3-methyl-1H-pyrazoles (3a-l) have been diazotised and coupled with 4-hydroxycoumarin to give rise to the coumarin-based disperse disazo dyes (3a-l). The newly synthesized twelve coumarin-based disperse disazo dyes have been characterized by using the elemental analysis and the spectral methods. The solvatochromic behavior of these dyes in various solvents is evaluated. Substituent, acid and base effects on the visible absorption spectra of the dyes substituted with electron-withdrawing and electron-donating groups at their o-, m-, p-position are also reported in detail. Molecular geometries and spectroscopic properties of the compounds considered in this work are also analyzed by using ab initio calculation methods based on the density functional theory (DFT) in the ground state. The theoretical results obtained from DFT are compatible with the experimental results.

Synthesis, solvatochromic properties and theoretical calculation of some novel disazo indole dyes

Synthesis of new disazo indole dyes (3a-3m) was carried out by diazotization of 5-amino-4-arylazo-3-methyl-1H-pyrazoles (2a-2m) and coupling with 2-phenyl indole. The newly synthesized 12 disperse disazo dyes were characterized by UV-vis, FT-IR, 1/s

Synthesis and absorption abilities of pyrazolo[5,1-c][1,2,4]triazine-based disperse dyes

A series of 13 novel pyrazolo[5,1-c][1,2,4]triazine-based disperse dyes was synthesized by heating ethyl pyrazolylhydrazonocyanoacetate in glacial acetic acid. Solvent and acid-base influences on the wavelength of maximum absorption have been studied.

Synthesis, solvatochromic properties and antimicrobial activities of some novel pyridone-based disperse disazo dyes

In this study, 5-amino-4-arylazo-3-methyl-1H-pyrazoles (2a-l) were diazotized and coupled with 3-cyano-6-hydroxy-4-methyl-2-pyridone to give pyridone-based disperse disazo dyes (3a-l). The newly synthesized twelve pyridone-based disperse disazo dyes were

Synthesis and tautomeric structure of 3,7-bis(arylazo)-2,6-dimethyl- 1Himidazo 1,2-b]pyrazoles

Three series of 3,7-bis(arylazo)-2,6-dimethyl-1H-imidazo[1,2-b]pyrazoles were prepared starting from N-aryl-2-oxopropanehydrazonoyl chlorides. The acid dissociation constants pKa were determined and correlated with the Hammett equation. The results of suc

Synthesis and tautomeric structure of 3,6-bis(arylazo)pyrazolo [1,5-a]pyrimidine-5,7(4H,6H)-diones

Two series of 3,6-bis(arylazo)pyrazolo[1,5-a]pyrimidine-5,7-diones were prepared, and their acid dissociation constant pKas were determined and correlated with the Hammett equation. The results of these correlations, together with the spectroscopic data, indicated that the title compounds exist predominantly in the 3-arylazo-6- arylhydrazonopyrazolo[1,5-a]pyrimidine-5,7- dione tautomeric form, both in the solid and solution phases.

STUDIES ON CONDENSED PYRAZOLES: SYNTHESIS OF NEW METHYL AND AMINO PYRAZOLOPYRIMIDINES AND OF PYRAZOLOTRIAZINES

A variety of 3-arylazo 5-amino- and 7-aminopyrazolo-pyrimidines were obtained via reacting Ia-Id with cinnamonitriles.The structure of products was confirmed via 1H NMR.Both 5-amino- and 7-amino-3-arylazo pyrazolopyrimidines reacted, with protons in acetic acid-sulphuric acid mixture to yield the corresponding 3-unsubstituted acetylaminopyrazolopyrimidines.Diazotized Ia and Ib coupled with a variety of active methylene reagents to yield pyrazolotriazines.