1256575-07-1Relevant academic research and scientific papers
Synthesis and biological activity of novel 2,5-disubstituted-l,3,4- oxadiazoles
Shailaja,Anitha,Manjula,Rao, B. Vittal
experimental part, p. 1088 - 1097 (2010/10/21)
A new and previously unreported molecular framework of 1,3,4-oxadiazoles incorporating halo pyridines has been synthesised. The derivatives are synthesised starting from substituted pyridinyloxy benzaldehydes, by converting them in to corresponding arylidene hydrazides followed by chloramine-T oxidation to the title compounds. The 2,5-disubstituted 1,3,4- oxadiazole derivatives are tested for antimicrobial activity. Many compounds showed high degree of activity against Staphylococus aureus and Escherichia coli bacteria at 250 μg/mL concentration.
