1256578-99-0Relevant articles and documents
Imatinib intermediate and synthesis method, intermediate thereof (by machine translation)
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Page/Page column 5-8, (2020/03/06)
The invention belongs to the technical field of medicines, and particularly relates to an imatinib intermediate and a synthesis method, intermediate. thereof, wherein 2 - (4 - hydroxyl - 5 5-methoxy- 2 2-propylphenyl) acetic acid is used as raw, raw material cheap and easily available, and the reaction step is short, reaction time, 98.150% yield can reach, or more 90.73% with good. industrial prospect. (by machine translation)
Four and circular Anaplastic lymphoma kinase inhibitors
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, (2017/08/25)
The invention belongs to the technical field of medicines, and particularly relates to a four-ring anaplastic lymphoma kinase inhibitor as shown in a general formula (I), or stereisomers, or pharmaceutically acceptable salts, esters or solvates of the inhibitor, wherein A1, A2, A3, M, X, Y, Q, R4, R5, R6, R7 and n are defined in the specification. The invention also relates to a preparation method of these compounds, pharmaceutical preparations and pharmaceutical compositions containing these compounds, and application of the compound or the stereisomers, or the pharmaceutically acceptable salts, esters or solvates of the compound in preparation of medicines for treating and/or preventing ALK-mediated cancer related diseases.
TETRACYCLIC COMPOUND
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Page/Page column 92, (2012/04/11)
A compound represented by the general Formula (I) below, or a salt or solvate thereof, which is useful as an ALK inhibitor, and is useful for prophylaxis or treatment of a disease accompanied by abnormality in ALK, for example, cancer, cancer metastasis,