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1256578-99-0

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1256578-99-0 Usage

Description

6-Bromo-7-Methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-one is a chemical compound that serves as an intermediate in the synthesis of Alectinib (C183360), a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor. 6-broMo-7-Methoxy-1,1-diMethyl-3,4-dihydronaphthalen-2(1H)-one, plays a crucial role in the development of pharmaceuticals targeting cancer treatment.

Uses

Used in Pharmaceutical Industry:
6-Bromo-7-Methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-one is used as a key intermediate in the synthesis of Alectinib, a potent ALK inhibitor. It contributes to the development of cancer therapeutics by targeting the resistant gatekeeper mutant, leading to reduced cell growth and improved treatment outcomes for patients with anaplastic lymphoma kinase-positive cancers.

Check Digit Verification of cas no

The CAS Registry Mumber 1256578-99-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,6,5,7 and 8 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1256578-99:
(9*1)+(8*2)+(7*5)+(6*6)+(5*5)+(4*7)+(3*8)+(2*9)+(1*9)=200
200 % 10 = 0
So 1256578-99-0 is a valid CAS Registry Number.

1256578-99-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2-one

1.2 Other means of identification

Product number -
Other names 6-bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1256578-99-0 SDS

1256578-99-0Relevant articles and documents

Imatinib intermediate and synthesis method, intermediate thereof (by machine translation)

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Page/Page column 5-8, (2020/03/06)

The invention belongs to the technical field of medicines, and particularly relates to an imatinib intermediate and a synthesis method, intermediate. thereof, wherein 2 - (4 - hydroxyl - 5 5-methoxy- 2 2-propylphenyl) acetic acid is used as raw, raw material cheap and easily available, and the reaction step is short, reaction time, 98.150% yield can reach, or more 90.73% with good. industrial prospect. (by machine translation)

Four and circular Anaplastic lymphoma kinase inhibitors

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, (2017/08/25)

The invention belongs to the technical field of medicines, and particularly relates to a four-ring anaplastic lymphoma kinase inhibitor as shown in a general formula (I), or stereisomers, or pharmaceutically acceptable salts, esters or solvates of the inhibitor, wherein A1, A2, A3, M, X, Y, Q, R4, R5, R6, R7 and n are defined in the specification. The invention also relates to a preparation method of these compounds, pharmaceutical preparations and pharmaceutical compositions containing these compounds, and application of the compound or the stereisomers, or the pharmaceutically acceptable salts, esters or solvates of the compound in preparation of medicines for treating and/or preventing ALK-mediated cancer related diseases.

TETRACYCLIC COMPOUND

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Page/Page column 92, (2012/04/11)

A compound represented by the general Formula (I) below, or a salt or solvate thereof, which is useful as an ALK inhibitor, and is useful for prophylaxis or treatment of a disease accompanied by abnormality in ALK, for example, cancer, cancer metastasis,

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