1256578-99-0

Basic information

• Product Name: 6-broMo-7-Methoxy-1,1-diMethyl-3,4-dihydronaphthalen-2(1H)-one,
• Synonyms: 6-broMo-7-Methoxy-1,1-diMethyl-3,4-dihydronaphthalen-2(1H)-one,;6-bromo-7-methoxy-1,1-dimethyl-3,4-dihydro-1H-naphthalen-2-one;6-Bromo-3,4-dihydro-7-methoxy-1,1-dimethyl-2(1H)-naphthalenone;6-broMo-7-Methoxy-1,1-diMethyl-3,4-dihydronaphthalen-2(1H)-on
• CAS NO: 1256578-99-0
• Molecular Formula: C13H15BrO2
• Molecular Weight: 283.161
• EINECS: -0
• Mol File: 1256578-99-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 354.7±42.0 °C(Predicted)
• Appearance: /
• Density: 1.339±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 6-broMo-7-Methoxy-1,1-diMethyl-3,4-dihydronaphthalen-2(1H)-one,(CAS DataBase Reference)
• NIST Chemistry Reference: 6-broMo-7-Methoxy-1,1-diMethyl-3,4-dihydronaphthalen-2(1H)-one,(1256578-99-0)
• EPA Substance Registry System: 6-broMo-7-Methoxy-1,1-diMethyl-3,4-dihydronaphthalen-2(1H)-one,(1256578-99-0)

Safety Data

• Hazardous Substances Data: 1256578-99-0(Hazardous Substances Data)

Usage

Description

6-Bromo-7-Methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-one is a chemical compound that serves as an intermediate in the synthesis of Alectinib (C183360), a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor. 6-broMo-7-Methoxy-1,1-diMethyl-3,4-dihydronaphthalen-2(1H)-one, plays a crucial role in the development of pharmaceuticals targeting cancer treatment.

Uses

Used in Pharmaceutical Industry:
6-Bromo-7-Methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-one is used as a key intermediate in the synthesis of Alectinib, a potent ALK inhibitor. It contributes to the development of cancer therapeutics by targeting the resistant gatekeeper mutant, leading to reduced cell growth and improved treatment outcomes for patients with anaplastic lymphoma kinase-positive cancers.

Upstream product

• 74-88-4 methyl iodide 
• 4133-34-0 7-methoxyl-2-tetralone 
• 1865-83-4 7-methoxy-1,1-dimethyl-3,4-dihydronaphthalene-2-(1H)-one 

Downstream Products

• 1256579-03-9 9-bromo-8-methoxy-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile 
• 1256579-06-2 9-bromo-8-hydroxy-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile 
• 1256579-00-6 9-bromo-8-methoxy-6,6-dimethyl-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile 
• 1256579-01-7 9-bromo-8-methoxy-6,6-dimethyl-6,11-dihydro-5H-benzo[b]carbazole-1-carbonitrile 

Relevant articles and documents

Imatinib intermediate and synthesis method, intermediate thereof (by machine translation)

The invention belongs to the technical field of medicines, and particularly relates to an imatinib intermediate and a synthesis method, intermediate. thereof, wherein 2 - (4 - hydroxyl - 5 5-methoxy- 2 2-propylphenyl) acetic acid is used as raw, raw material cheap and easily available, and the reaction step is short, reaction time, 98.150% yield can reach, or more 90.73% with good. industrial prospect. (by machine translation)

Four and circular Anaplastic lymphoma kinase inhibitors

The invention belongs to the technical field of medicines, and particularly relates to a four-ring anaplastic lymphoma kinase inhibitor as shown in a general formula (I), or stereisomers, or pharmaceutically acceptable salts, esters or solvates of the inhibitor, wherein A1, A2, A3, M, X, Y, Q, R4, R5, R6, R7 and n are defined in the specification. The invention also relates to a preparation method of these compounds, pharmaceutical preparations and pharmaceutical compositions containing these compounds, and application of the compound or the stereisomers, or the pharmaceutically acceptable salts, esters or solvates of the compound in preparation of medicines for treating and/or preventing ALK-mediated cancer related diseases.

TETRACYCLIC COMPOUND

A compound represented by the general Formula (I) below, or a salt or solvate thereof, which is useful as an ALK inhibitor, and is useful for prophylaxis or treatment of a disease accompanied by abnormality in ALK, for example, cancer, cancer metastasis,