1256635-33-2Relevant academic research and scientific papers
Convenient synthesis and antibacterial activity of tricyclic azine derivatives
Elassar, Abdel-Zaher A.,Alsughayer, Abdulhakeem,Sagheer, Fakhreia Al
, p. 248 - 252 (2013)
1,4-Phenylenediamine reacted readily with 2 mol of ethyl acetoacetate to give diethyl (2Z,2′Z)-3,3′-[(1,4-phenylene)- bisimino]dibut-2- enoate, which reacted with dimethylformamide dimethylacetal, activated methylene nitriles, ylidenemalononitriles and phenyl and benzoyl isothiocyanate to give, respectively, a 4,7-phenanthroline-2,9-dicarboxylate- 1,10-diol, and tricyclic bispyridine and bispyrimidine derivatives. Two compounds showed strong antibacterial activity against several microorganisms, while six others showed high to moderate activity.
