1256700-69-2

Upstream product

• 1256700-78-3 5-trifluoromenthyl-(1-(4-amino-2-chloro)phenyl)pyridine-2(1H)-one 
• 107-07-3 2-chloro-ethanol 
• 350-30-1 3-chloro-4-fluoronitrobenzene 
• 33252-63-0 5-(trifluoromethyl)-2(1H)-pyridone 
• 1256700-77-2 1-(2-chloro-4-nitrophenyl)-5-(trifluoromethyl)pyridin-2(1H)-one 
• 1365919-82-9 2-chloro-5-trifluoromethyl-pyridine 

Relevant academic research and scientific papers

PREPARATION METHODS AND USES OF 1-(SUBSTITUTED ARYL)-5-TRIFLUOROMETHYL-2-(1H)-PYRIDONE COMPOUNDS AND THEIR SALTS

A 1-(substituted aryl)-5-trifluoromethyl-2-(1H)pyridone compounds and pharmaceutical acceptable salts, preparation methods and uses for preparing the drugs for treating fibrosis thereof.

Synthesis and structure-activity relationship of 5-substituent-2(1H)- pyridone derivatives as anti-fibrosis agents

Pyridone compounds, such as pirfenidone (PFD) and fluorofenidone (AKF-PD), are multi-target anti-fibrotic agents. Using PFD and AKF-PD as the leading compounds, two series of novel (5-substituent)-2(1H)-pyridone compounds were synthesized with the purpose of maintaining multi-targeting property and overcoming the drawbacks of fast metabolism. These derivatives demonstrated good proliferation inhibiting activity against NIH3T3 cells by MTT assay with AKF-PD as the positive control. Compound 5b exhibited a high potent of anti-fibrosis with a IC50 of 0.08 mmol/L about 34 times of AKF-PD. The SAR of pyridone derivatives as anti-fibrosis agents was also discussed.