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CAS

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1256768-39-4

[2-(3-nitrobenzyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide-4-yl]acetic acid methyl ester is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1256768-39-4 Structure

  • Basic information

    1. Product Name: [2-(3-nitrobenzyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide-4-yl]acetic acid methyl ester
    2. Synonyms: [2-(3-nitrobenzyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide-4-yl]acetic acid methyl ester
    3. CAS NO:1256768-39-4
    4. Molecular Formula:
    5. Molecular Weight: 391.404
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1256768-39-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: [2-(3-nitrobenzyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide-4-yl]acetic acid methyl ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: [2-(3-nitrobenzyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide-4-yl]acetic acid methyl ester(1256768-39-4)
    11. EPA Substance Registry System: [2-(3-nitrobenzyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide-4-yl]acetic acid methyl ester(1256768-39-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1256768-39-4(Hazardous Substances Data)

1256768-39-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1256768-39-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,6,7,6 and 8 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1256768-39:
(9*1)+(8*2)+(7*5)+(6*6)+(5*7)+(4*6)+(3*8)+(2*3)+(1*9)=194
194 % 10 = 4
So 1256768-39-4 is a valid CAS Registry Number.

1256768-39-4Relevant articles and documents

Acetic acid derivatives of 3,4-dihydro-2 H-1,2,4-benzothiadiazine 1,1-dioxide as a novel class of potent aldose reductase inhibitors

Chen, Xin,Zhu, Changjin,Guo, Fan,Qiu, Xiaowei,Yang, Yanchun,Zhang, Shuzhen,He, Minlan,Parveen, Shagufta,Jing, Chaojun,Li, Yan,Ma, Bing

experimental part, p. 8330 - 8344 (2011/02/23)

A series of novel benzothiadiazine 1,1-dioxide derivatives were synthesized and tested for their inhibitory activity against aldose reductase. Of these derivatives, 17 compounds, having a substituted N2-benzyl group and a N4-acetic acid group on the benzothiadiazine, were found to be potent and selective aldose reductase inhibitors in vitro with IC50 values ranging from 0.032 to 0.975 μM. 9m proved to be the most active in vitro. The eight top-scoring compounds coming from the in vitro test for ALR2 inhibition activity were then tested in vivo, whereby three derivatives, 9i, 9j, and 9m, demonstrated a significantly preventive effect on sorbitol accumulation in the sciatic nerve in the 5-day streptozotocin-induced diabetic rats in vivo. Structure-activity relationship and molecular docking studies highlighted the importance of substitution features of N4-acetic acid group and halogen-substituted N2-benzyl group in the benzothiadiazine scaffold and indicated that substitution with hallogen at C-7 had a remarkably strong effect on ALR2 inhibition potency.

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