1256777-39-5Relevant articles and documents
A synthesis of dihydroimidazo[5,1-a]isoquinolines using a sequential Ugi-Bischler-Napieralski reaction sequence
Seganish, W. Michael,Bercovici, Ana,Ho, Ginny D.,Loozen, Hubert J.J.,Timmers, Cornelis M.,Tulshian, Deen
, p. 903 - 905 (2012/03/10)
A flexible route to analogues of dihydroimidazo[5,1-a]isoquinolines is described. The synthesis hinges on a sequential Ugi coupling, followed by a Bischler-Napieralski reaction to form the imidazole isoquinoline core. This route facilitates the introduction of a range of substitutions throughout the carbon framework.