1256944-08-7Relevant academic research and scientific papers
Inhibition of gastric H+, K+-ATPase by novel thiazolidinone derivatives
Chandrappa,Vinaya,Srikanta,Ananda Kumar,Prasanna,Thimmegowda,Dharmesh, Shylaja M.,Rangappa
experimental part, p. 189 - 196 (2010/11/18)
In a program to identify new anti-ulcer compounds, a series of novel substituted thiazolidinone derivatives 5(a-j) were synthesized and screened for their in vitro H+, K+-ATPase inhibitory activity. The synthesized compounds were characterized by nuclear magnetic resonance ( 1H-NMR), liquid chromatography-mass spectrometry (LCMS) and fourier transform infrared (FTIR) analysis. We have briefly investigated the structure-activity relation (SAR) studies and reveal that the nature of position of the fluorine atom influences the anti-ulcer activity. Among the synthesized compounds 5b, 5c and 5e showed 4 and 10-fold higher H+, K +-ATPase activity when compared with those of other derivatives 5a, 5f, 5g and 5j, respectively. H+, K+-ATPase activity of 5b, 5c and 5e were comparable with those of known H+, K +-ATPase blocker lansoprazole which is a potential anti-ulcer drug.
