1256945-18-2Relevant academic research and scientific papers
Effect of milrinone analogues on intracellular calcium increase in single living H9C2 cardiac cells
Pietrangelo, Tiziana,Giampietro, Letizia,De Filippis, Barbara,La Rovere, Rita,Fulle, Stefania,Amoroso, Rosa
, p. 4928 - 4933 (2010)
The synthesis of milrinone analogues where the 4-pyridyl moiety was replaced by an ester or amide group is reported. Only amide derivatives are able to support intracellular calcium influx following chemical depolarization with 60 mM KCl in a percentage varying from 20 to 45% of differentiated H9C2 cardiomyocytes. Those cells were differentiated after chronic exposure to 10 nM retinoic acid which induces the expression of voltage-gated calcium channels. Analogues of milrinone containing an ester function did not show significant activity.
