1256947-81-5Relevant articles and documents
Synthesis and biological evaluation of new indazole derivatives
Plescia, Salvatore,Raffa, Demetrio,Plescia, Fabiana,Casula, Giovanni,Maggio, Benedetta,Daidone, Giuseppe,Raimondi, Maria Valeria,Cusimano, Maria Grazia,Bombieri, Gabriella,Meneghetti, Fiorella
experimental part, p. 163 - 177 (2010/12/25)
New N-methyl and N-ethyl substitutions in the indazole nucleus are reported by reacting 3-(2-aminobenzamido)indazole and the appropriate trimethyl/triethyl orthobenzoate. Single crystal X-ray analysis confirms the N-ethylation position for the 3-(1-ethyl-1H-indazol-3-yl)-2-phenylquinazolin-4(3H)-one derivative 3f. Compounds 11a-d and 3a-d were tested to evaluate their antimicrobial, antiproliferative and COX inhibitory activities, showing scarce or moderately antiproliferative activity and some inhibitory activity against COX-1 and COX-2. ARKAT USA, Inc.