1256963-23-1

Basic information

• Product Name: 4-[6-(benzhydrylideneamino)-pyridazin-3-yl]-piperazine-1-carboxylic acid tert-butyl ester
• Synonyms: 4-[6-(benzhydrylideneamino)-pyridazin-3-yl]-piperazine-1-carboxylic acid tert-butyl ester
• CAS NO: 1256963-23-1
• Molecular Weight: 443.549
• Mol File: 1256963-23-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-[6-(benzhydrylideneamino)-pyridazin-3-yl]-piperazine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[6-(benzhydrylideneamino)-pyridazin-3-yl]-piperazine-1-carboxylic acid tert-butyl ester(1256963-23-1)
• EPA Substance Registry System: 4-[6-(benzhydrylideneamino)-pyridazin-3-yl]-piperazine-1-carboxylic acid tert-butyl ester(1256963-23-1)

Safety Data

• Hazardous Substances Data: 1256963-23-1(Hazardous Substances Data)

Upstream product

• 1013-88-3 Benzophenone imine 
• 492431-11-5 4-(6-chloro-pyridazin-3-yl)-piperazine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

4-(pyrazol-4-yl)-pyrimidines as selective inhibitors of cyclin-dependent kinase 4/6

Identification and structure-guided optimization of a series of 4-(pyrazol-4-yl)-pyrimidines as selective CDK4/6 inhibitors is reported herein. Several potency and selectivity determinants were established based on the X-ray crystallographic analysis of representative compounds bound to monomeric CDK6. Significant selectivity for CDK4/6 over CDK1 and CDK2 was demonstrated with several compounds in both enzymatic and cellular assays.

PYRIDO[3, 4-D]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF

The purpose of the present invention is to provide a compound that has excellent CDK4/6 inhibitory activity. The present invention is a compound represented by formula (I) or a pharmaceutically acceptable salt of the compound.