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1257044-40-8

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Product FOB Price Min.Order Supply Ability Supplier
Venetoclax
Cas No: 1257044-40-8
No Data 1 Gram 1000 Gram/Week Shanghai BetterBioChem Co., Ltd. Contact Supplier
venetoclax
Cas No: 1257044-40-8
No Data No Data Metric Ton/Day Beijing Mesochem Technology Co.,LTD Contact Supplier
1257044-40-8/Venetoclax
Cas No: 1257044-40-8
No Data 1 Milligram hundreds of Kilogram/Month Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd Contact Supplier
Good Price/Top Quality 99.0%, Venetoclax ABT - 199 API Powder
Cas No: 1257044-40-8
USD $ 1.0-10.0 / Gram 1 Gram 500 Kilogram/Month Beijing Yibai Biotechnology Co., Ltd Contact Supplier
Venetoclax ABT-199
Cas No: 1257044-40-8
No Data 1 Kilogram 500 Kilogram/Month Huarong Industrial Group Ltd. Contact Supplier
ABT-199 (GDC-0199)Venetoclax
Cas No: 1257044-40-8
No Data 100 Gram 1 Metric Ton/Month Senova Technology Company Limited Contact Supplier
Venetoclax
Cas No: 1257044-40-8
No Data No Data No Data Hangzhou Cherry Pharmaceutical Technology Co., Ltd. Contact Supplier
ABT-199
Cas No: 1257044-40-8
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
Venetoclax
Cas No: 1257044-40-8
No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
ABT-199
Cas No: 1257044-40-8
USD $ 5.0-5.0 / Kilogram 1 Kilogram 1000 Kilogram/Month Enke Pharma-tech Co.,Ltd. (Cangzhou, China ) Contact Supplier

1257044-40-8 Usage

References

https://en.wikipedia.org/wiki/Venetoclax
Vogler, M, et al. "ABT-199 selectively inhibits BCL2 but not BCL2L1 and efficiently induces apoptosis of chronic lymphocytic leukaemic cells but not platelets." British Journal of Haematology 163.1(2013):139-42.
Vaillant, François, et al. "Targeting BCL-2 with the BH3 Mimetic ABT-199 in Estrogen Receptor-Positive Breast Cancer." Cancer Cell 24.1(2013):120-9.
Lindeman, G. J., et al. "Abstract P2-09-01: Targeting BCL-2 with the BH3 mimetic ABT-199 in ER-positive breast cancer." Cancer Research 73.24 Supplement (2013):P2-09-01-P2-09-01.

Definition

ChEBI: A member of the class of pyrrolopyridines that is a potent inhibitor of the antiapoptotic protein B-cell lymphoma 2. It is used for treamtment of chronic lymphocytic leukemia with 17p deletion.

Description

ABT-199, also known as venetoclax, is a small, oral chemical molecule used for the treatment of chronic lymphocytic leukemia (CLL) associated with a specific chromosomal abnormality. As a second line treatment drug of CLL, ABT-199 take effects through acting as a BH3-mimetic and inhibitor of Bcl-2 (the anti-apoptotic B-cell lymphoma-2protein), further inducing apoptosis of CLL cells but not platelets. It also has the potential for the treatment of ER-positive breast cancer.

1257044-40-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name ABT199

1.2 Other means of identification

Product number -
Other names 4-[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]-N-[3-nitro-4-(oxan-4-ylmethylamino)phenyl]sulfonyl-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1257044-40-8 SDS

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