1257044-57-7

Basic information

• Product Name: methyl 2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-4-(piperazin-1-yl)benzoate
• Synonyms: methyl 2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-4-(piperazin-1-yl)benzoate
• CAS NO: 1257044-57-7
• Molecular Formula: C19H20N4O3
• Molecular Weight: 352.3871
• Mol File: 1257044-57-7.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: methyl 2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-4-(piperazin-1-yl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-4-(piperazin-1-yl)benzoate(1257044-57-7)
• EPA Substance Registry System: methyl 2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-4-(piperazin-1-yl)benzoate(1257044-57-7)

Safety Data

• Hazardous Substances Data: 1257044-57-7(Hazardous Substances Data)

Usage

General Description

Methyl 2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-4-(piperazin-1-yl)benzoate is a compound consisting of a methyl ester group attached to a 2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-4-(piperazin-1-yl)benzoate moiety. This chemical is a potential drug candidate and has been studied for its pharmacological properties. It is believed to have affinity for certain receptors in the central nervous system and may have potential applications in the treatment of neurological disorders. Further research is needed to fully understand the potential uses and effects of this compound.

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Relevant articles and documents

Potential applications of BPFP1 in Bcl-2 protein quantification, carcinoma cell visualization, cell sorting and early cancer diagnosis

Overexpression of the Bcl-2 protein has emerged as a hallmark of carcinoma cells and can be employed as a biochemical biomarker of these cells. Therefore, some Bcl-2 protein fluorescence probes (BPFPs) were designed for Bcl-2 protein quantification and carcinoma cells labeling. The high Bcl-2 protein binding affinity (Ki a range of concentrations of Bcl-2 protein, BPFP1 exhibited the desired fluorescence properties and its fluorescence intensity is proportional to Bcl-2 protein concentration. Therefore, BPFP1 provides a convenient approach for Bcl-2 protein quantification and we could determine the concentration of Bcl-2 protein based on the BPFP1's fluorescence intensity. Subsequent studies revealed that BPFP1 can fluorescently label carcinoma cells by binding to overexpressed Bcl-2 protein in living cells, and can distinguish carcinoma cells (HL-60 cells and ACHN cells) from normal-tissue cells (HUVECs) according to the different Bcl-2 protein expression levels between carcinoma cells and normal tissue cells. In the present study, BPFP1 represents a new tool for Bcl-2 protein quantification, carcinoma cell visualization and cell sorting. Moreover, BPFP1 can be used in the future for early cancer diagnosis by detecting carcinoma cells in patient tissues.

Preparation method of Venetoclax intermediate

The invention belongs to the field of medicinal chemistry. The invention mainly relates to a preparation method of a Venetoclax intermediate (I) methyl-2-(1H-pyrrole [2, 3-B] pyridine-5-oxy)-4-(piperazine-1-yl) benzoate. The preparation method comprises t

PROCESS FOR THE PREPARATION OF VENETOCLAX

The present disclosure provides novel synthetic process for the preparation of venetoclax. The disclosed processes involve the use of novel intermediates. Processes for the preparation of these intermediates are also disclosed as well as methods for the preparation of particularly useful salts thereof.