1257063-96-9Relevant articles and documents
Efficient synthesis of arylated flavones by site-selective Suzuki-Miyaura cross-coupling reactions of the bis(triflate) of 5,7- and 7,8-dihydroxyflavone
Eleya, Nadi,Malik, Imran,Reimann, Sebastian,Wittler, Kai,Hein, Martin,Patonay, Tamas,Villinger, Alexander,Ludwig, Ralf,Langer, Peter
, p. 1639 - 1652 (2012/04/18)
Suzuki-Miyaura reactions of the bis(triflate) of 5,7- and 7,8-dihydroxyflavone proceed with very good site selectivity in favor of position 7 and allow the synthesis of various arylated flavones. The reaction of 5,7-dihydroxyflavone with one equivalent of triflic anhydride also proceeds with very good site selectivity in favor of position 7. The subsequent Suzuki-Miyaura reaction of the product allows the synthesis of 7-aryl-5-hydroxyflavones. The regioselectivity is discussed based on DFT calculations.