1257129-43-3Relevant academic research and scientific papers
A novel approach for the solid-phase organic synthesis of 1,3-disubstituted uracils
Wei, Mei-Hong,Lin, Shu-Ying,Sheng, Sheng-Ri,Wang, Qing,Cai, Ming-Zhong
, p. 300 - 304 (2010)
A novel procedure for solid-phase organic synthesis of 1,3-disubstituted uracils using a cyclizationcleavage strategy from Wang-acrylate resin, amines and isocyanates. An acrylate ester resin is reacted in turn with PhSeBr and primary amines in one-pot to afford N-substituted α-phenylseleno-β- aminoesters followed by treatment with isocyanates to form α-phenylseleno- β-ureidoester resin. Following oxidation-elimination with excess of 30% hydrogen peroxide and intramolecular cyclization cleavage of the Wang resin using potassium ethoxide as a base to furnish 1,3-disubstituted uracils in good yields (80-86%) and high purities (92-96%).
