1257213-07-2Relevant academic research and scientific papers
Asymmetric synthesis of synthetic alkaloids by a tandem biocatalysis/Ugi/Pictet-Spengler-type cyclization sequence
Znabet, Anass,Zonneveld, Job,Janssen, Elwin,De Kanter, Frans J. J.,Helliwell, Madeleine,Turner, Nicholas J.,Ruijter, Eelco,Orru, Romano V. A.
supporting information; experimental part, p. 7706 - 7708 (2010/11/18)
We have combined the biocatalytic desymmetrization of 3,4-cis-substituted meso-pyrrolidines with an Ugi-type multicomponent reaction followed in situ by a Pictet-Spengler-type cyclization reaction sequence for the rapid asymmetric synthesis of alkaloid-like polycyclic compounds. The Royal Society of Chemistry.
