1257231-36-9Relevant academic research and scientific papers
Efficient and general asymmetric syntheses of (R)-chroman-4-amine salts
Voight, Eric A.,Daanen, Jerome F.,Hannick, Steven M.,Shelat, Bhadra H.,Kerdesky, Francis A.,Plata, Daniel J.,Kort, Michael E.
, p. 5904 - 5907 (2010)
Starting from a variety of substituted chroman-4-ones, a highly enantioselective CBS reduction using in situ-generated B-H catalyst gave (S)-chroman-4-ols. Azide inversion and reduction gave crude (R)-chroman-4- amines, which could be purified without chromatography by isolation as the (R)-mandelic or d-tartaric acid salts with good yields and excellent ee.
